Drug interactions
Brexpiprazole + Lurasidone
Severity: Moderate
Brexpiprazole and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are atypical antipsychotics that cause somnolence, akathisia and orthostatic effects. Using them together adds adverse effects without a well-established benefit.
What this interaction means in plain words
Brexpiprazole and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Lurasidone belongs to Central Nervous System.
Why it happens
Additive CNS depression and dopamine/serotonin receptor effects (pharmacodynamic).
What to do
Avoid combining antipsychotics unless clearly justified. Monitor sedation, movement disorders, blood pressure and metabolic parameters.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Brexpiprazole with Lurasidone?
MediHelp rates the interaction as moderate. Brexpiprazole and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are atypical antipsychotics that cause somnolence, akathisia and orthostatic effects. Using them together adds adverse effects without a well-established benefit.
How serious is the interaction between Brexpiprazole and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining antipsychotics unless clearly justified. Monitor sedation, movement disorders, blood pressure and metabolic parameters.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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