Drug interactions
Brexpiprazole + Perphenazine
Severity: Moderate
Brexpiprazole and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, so combined use may increase drowsiness and impair alertness. Perphenazine may also raise brexpiprazole exposure since both involve CYP2D6.
What this interaction means in plain words
Brexpiprazole and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Perphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression; perphenazine may inhibit CYP2D6 metabolism of brexpiprazole.
What to do
Warn the patient about drowsiness and monitor for sedation, orthostasis and extrapyramidal symptoms. Adjust the dose of either agent if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Perphenazine?
MediHelp rates the interaction as moderate. Brexpiprazole and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, so combined use may increase drowsiness and impair alertness. Perphenazine may also raise brexpiprazole exposure since both involve CYP2D6.
How serious is the interaction between Brexpiprazole and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn the patient about drowsiness and monitor for sedation, orthostasis and extrapyramidal symptoms. Adjust the dose of either agent if adverse effects occur.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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