Drug interactions
Brexpiprazole + Promethazine
Severity: Moderate
Brexpiprazole and Promethazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause sedation, so combined use can increase drowsiness, dizziness and psychomotor impairment. Orthostatic hypotension may also be additive.
What this interaction means in plain words
Brexpiprazole and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Promethazine belongs to Respiratory.
Why it happens
Additive CNS depression through histamine H1 and other receptor blockade.
What to do
Monitor for excessive sedation and orthostatic hypotension, and advise patients to avoid driving until the response is known. Reduce the promethazine dose if sedation is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Promethazine
- Cabergoline + Promethazine Contraindicated
- Dopamine + Promethazine Contraindicated
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
Other interactions of Brexpiprazole
Frequently asked questions
Can I take Brexpiprazole with Promethazine?
MediHelp rates the interaction as moderate. Brexpiprazole and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents cause sedation, so combined use can increase drowsiness, dizziness and psychomotor impairment. Orthostatic hypotension may also be additive.
How serious is the interaction between Brexpiprazole and Promethazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and orthostatic hypotension, and advise patients to avoid driving until the response is known. Reduce the promethazine dose if sedation is troublesome.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Cabergoline, Dopamine, Ibutilide. The full list is on the Promethazine page.
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