Drug interactions
Brexpiprazole + Ribociclib
Severity: Moderate
Brexpiprazole and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate to strong CYP3A4 inhibitor, and brexpiprazole is cleared partly by CYP3A4 and CYP2D6. Exposure to brexpiprazole may rise, increasing sedation, orthostasis and other adverse effects. Ribociclib also prolongs the QT interval, which adds a pharmacodynamic concern.
What this interaction means in plain words
Brexpiprazole and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Ribociclib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated brexpiprazole metabolism by ribociclib, plus additive QT effects.
What to do
Monitor for brexpiprazole adverse effects and consider dose reduction if they develop, noting the label advises halving the dose with strong CYP3A4 inhibitors. Obtain an ECG and check electrolytes in line with ribociclib monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Brexpiprazole with Ribociclib?
MediHelp rates the interaction as moderate. Brexpiprazole and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib is a moderate to strong CYP3A4 inhibitor, and brexpiprazole is cleared partly by CYP3A4 and CYP2D6. Exposure to brexpiprazole may rise, increasing sedation, orthostasis and other adverse effects. Ribociclib also prolongs the QT interval, which adds a pharmacodynamic concern.
How serious is the interaction between Brexpiprazole and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for brexpiprazole adverse effects and consider dose reduction if they develop, noting the label advises halving the dose with strong CYP3A4 inhibitors. Obtain an ECG and check electrolytes in line with ribociclib monitoring.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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