Drug interactions
Brexpiprazole + Tecovirimat
Severity: Minor
Brexpiprazole and Tecovirimat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tecovirimat is a weak inducer of CYP3A4 and may modestly lower brexpiprazole exposure, since brexpiprazole is cleared partly by CYP3A4. The reduction is expected to be small, but it could blunt antipsychotic effect in some patients during a tecovirimat course.
What this interaction means in plain words
Brexpiprazole and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brexpiprazole belongs to Central Nervous System; Tecovirimat belongs to Miscellaneous.
Why it happens
Weak induction of CYP3A4 by tecovirimat increases the metabolism of brexpiprazole.
What to do
No empirical dose change is usually needed; monitor for loss of psychiatric symptom control during and shortly after tecovirimat therapy. Consider adjusting the brexpiprazole dose if clinical response clearly declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Brexpiprazole and Tecovirimat, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Brexpiprazole
Other interactions of Tecovirimat
- Bosentan + Tecovirimat Moderate
- Cyclosporin + Tecovirimat Moderate
- Darunavir + Tecovirimat Moderate
- Ethinyl estradiol-drospirenone + Tecovirimat Moderate
- Ethinyl estradiol-levonorgestrel + Tecovirimat Moderate
- Glimepiride-pioglitazone + Tecovirimat Moderate
Frequently asked questions
Can I take Brexpiprazole with Tecovirimat?
MediHelp rates the interaction as minor. Brexpiprazole and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tecovirimat is a weak inducer of CYP3A4 and may modestly lower brexpiprazole exposure, since brexpiprazole is cleared partly by CYP3A4. The reduction is expected to be small, but it could blunt antipsychotic effect in some patients during a tecovirimat course.
How serious is the interaction between Brexpiprazole and Tecovirimat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is usually needed; monitor for loss of psychiatric symptom control during and shortly after tecovirimat therapy. Consider adjusting the brexpiprazole dose if clinical response clearly declines.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
