Drug interactions
Brexpiprazole + Temazepam
Severity: Moderate
Brexpiprazole and Temazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so combined use can increase drowsiness, dizziness, impaired psychomotor performance and fall risk. Elderly or frail patients are particularly vulnerable.
What this interaction means in plain words
Brexpiprazole and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brexpiprazole belongs to Central Nervous System; Temazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression through antihistaminic and adrenergic blockade from brexpiprazole plus GABA-A potentiation from temazepam.
What to do
Use the lowest effective temazepam dose and monitor for excessive sedation and falls, especially after initiation or dose increases. Advise patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Brexpiprazole
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Brexpiprazole with Temazepam?
MediHelp rates the interaction as moderate. Brexpiprazole and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so combined use can increase drowsiness, dizziness, impaired psychomotor performance and fall risk. Elderly or frail patients are particularly vulnerable.
How serious is the interaction between Brexpiprazole and Temazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective temazepam dose and monitor for excessive sedation and falls, especially after initiation or dose increases. Advise patients to avoid driving and alcohol.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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