Drug interactions
Brexpiprazole + Tipranavir
Severity: Major
Brexpiprazole and Tipranavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, taken with ritonavir, inhibits CYP3A4 and can raise brexpiprazole levels. However, tipranavir also has inducing effects, so the net result is less predictable. Higher exposure raises the risk of sedation, akathisia and orthostasis.
What this interaction means in plain words
Brexpiprazole and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Brexpiprazole belongs to Central Nervous System; Tipranavir belongs to Anti Virals.
Why it happens
Ritonavir-boosted tipranavir inhibits CYP3A4 metabolism of brexpiprazole, with possible partial offsetting induction.
What to do
Use half the usual brexpiprazole dose with strong CYP3A4 inhibitors, and a quarter if a CYP2D6 inhibitor is also present. Monitor tolerability and response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Brexpiprazole
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Brexpiprazole with Tipranavir?
MediHelp rates the interaction as major. Brexpiprazole and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tipranavir, taken with ritonavir, inhibits CYP3A4 and can raise brexpiprazole levels. However, tipranavir also has inducing effects, so the net result is less predictable. Higher exposure raises the risk of sedation, akathisia and orthostasis.
How serious is the interaction between Brexpiprazole and Tipranavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use half the usual brexpiprazole dose with strong CYP3A4 inhibitors, and a quarter if a CYP2D6 inhibitor is also present. Monitor tolerability and response.
What other medicines interact with Brexpiprazole?
MediHelp also lists interactions of Brexpiprazole with, for example, Alfentanil, Amisulpride, Apalutamide. The full list is on the Brexpiprazole page.
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