Drug interactions
Brigatinib + Itraconazole
Severity: Major
Brigatinib and Itraconazole: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole increases brigatinib exposure, which may worsen pulmonary toxicity, hypertension, bradycardia, pancreatic enzyme elevations and other adverse effects.
What this interaction means in plain words
Brigatinib and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Brigatinib belongs to Oncology; Itraconazole belongs to Anti Fungals.
Why it happens
Itraconazole strongly inhibits CYP3A4, the main metabolic pathway of brigatinib.
What to do
Avoid the combination if possible. If unavoidable, reduce the brigatinib dose by about half per labeling and restore the prior dose after itraconazole is stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Brigatinib
Frequently asked questions
Can I take Brigatinib with Itraconazole?
MediHelp rates the interaction as major. Brigatinib and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole increases brigatinib exposure, which may worsen pulmonary toxicity, hypertension, bradycardia, pancreatic enzyme elevations and other adverse effects.
How serious is the interaction between Brigatinib and Itraconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If unavoidable, reduce the brigatinib dose by about half per labeling and restore the prior dose after itraconazole is stopped.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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