Drug interactions
Brigatinib + Midazolam
Severity: Moderate
Brigatinib and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brigatinib induces CYP3A4 and may lower midazolam concentrations, potentially reducing its sedative or anxiolytic effect. The effect is of uncertain magnitude, being based largely on in vitro data.
What this interaction means in plain words
Brigatinib and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brigatinib belongs to Oncology; Midazolam belongs to Central Nervous System.
Why it happens
Brigatinib induces CYP3A4, increasing midazolam metabolism.
What to do
Monitor for reduced midazolam effect and titrate the dose to response. Consider an alternative not metabolized by CYP3A4 if efficacy is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Brigatinib
Frequently asked questions
Can I take Brigatinib with Midazolam?
MediHelp rates the interaction as moderate. Brigatinib and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brigatinib induces CYP3A4 and may lower midazolam concentrations, potentially reducing its sedative or anxiolytic effect. The effect is of uncertain magnitude, being based largely on in vitro data.
How serious is the interaction between Brigatinib and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced midazolam effect and titrate the dose to response. Consider an alternative not metabolized by CYP3A4 if efficacy is lost.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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