Drug interactions
Brigatinib + Ribociclib
Severity: Moderate
Brigatinib and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib inhibits CYP3A4, which metabolizes brigatinib, so brigatinib exposure may rise. This could increase pulmonary toxicity, hypertension, bradycardia and other adverse effects.
What this interaction means in plain words
Brigatinib and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brigatinib belongs to Oncology; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibition of CYP3A4 reduces brigatinib clearance.
What to do
Where possible choose an alternative. If used together, reduce the brigatinib dose per labeling for moderate CYP3A inhibitors and monitor for toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Brigatinib
Frequently asked questions
Can I take Brigatinib with Ribociclib?
MediHelp rates the interaction as moderate. Brigatinib and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib inhibits CYP3A4, which metabolizes brigatinib, so brigatinib exposure may rise. This could increase pulmonary toxicity, hypertension, bradycardia and other adverse effects.
How serious is the interaction between Brigatinib and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible choose an alternative. If used together, reduce the brigatinib dose per labeling for moderate CYP3A inhibitors and monitor for toxicity.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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