Drug interactions
Brigatinib + Rimegepant
Severity: Moderate
Brigatinib and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brigatinib is a weak to moderate CYP3A4 inducer and may lower rimegepant exposure. Reduced efficacy for acute migraine is possible.
What this interaction means in plain words
Brigatinib and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brigatinib belongs to Oncology; Rimegepant belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 increases rimegepant clearance.
What to do
Avoid concurrent use where possible and select another acute migraine treatment. If used, monitor for reduced response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rimegepant
Other interactions of Brigatinib
Frequently asked questions
Can I take Brigatinib with Rimegepant?
MediHelp rates the interaction as moderate. Brigatinib and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brigatinib is a weak to moderate CYP3A4 inducer and may lower rimegepant exposure. Reduced efficacy for acute migraine is possible.
How serious is the interaction between Brigatinib and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible and select another acute migraine treatment. If used, monitor for reduced response.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Atazanavir, Butabarbital. The full list is on the Rimegepant page.
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