Drug interactions
Brigatinib + Tacrolimus
Severity: Moderate
Brigatinib and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brigatinib may induce CYP3A4 and lower tacrolimus concentrations, risking subtherapeutic immunosuppression and graft rejection. The effect is largely based on in vitro data.
What this interaction means in plain words
Brigatinib and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brigatinib belongs to Oncology; Tacrolimus belongs to Miscellaneous.
Why it happens
CYP3A4 induction increases tacrolimus metabolism.
What to do
Monitor tacrolimus trough levels after starting or stopping brigatinib and adjust the tacrolimus dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Brigatinib
Frequently asked questions
Can I take Brigatinib with Tacrolimus?
MediHelp rates the interaction as moderate. Brigatinib and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brigatinib may induce CYP3A4 and lower tacrolimus concentrations, risking subtherapeutic immunosuppression and graft rejection. The effect is largely based on in vitro data.
How serious is the interaction between Brigatinib and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough levels after starting or stopping brigatinib and adjust the tacrolimus dose accordingly.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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