Drug interactions
Brigatinib + Voriconazole
Severity: Major
Brigatinib and Voriconazole: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole raises brigatinib exposure by inhibiting its CYP3A4 metabolism. Higher levels may increase the risk of pulmonary toxicity, hypertension, bradycardia, pancreatic enzyme elevation and visual disturbances.
What this interaction means in plain words
Brigatinib and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Brigatinib belongs to Oncology; Voriconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition decreases brigatinib clearance.
What to do
Avoid if possible; otherwise reduce the brigatinib dose by about half as labeled and monitor for respiratory symptoms and blood pressure. Restore the prior dose after voriconazole is stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Brigatinib
Frequently asked questions
Can I take Brigatinib with Voriconazole?
MediHelp rates the interaction as major. Brigatinib and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voriconazole raises brigatinib exposure by inhibiting its CYP3A4 metabolism. Higher levels may increase the risk of pulmonary toxicity, hypertension, bradycardia, pancreatic enzyme elevation and visual disturbances.
How serious is the interaction between Brigatinib and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise reduce the brigatinib dose by about half as labeled and monitor for respiratory symptoms and blood pressure. Restore the prior dose after voriconazole is stopped.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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