Drug interactions
Brimonidine + Chlorpromazine
Severity: Minor
Brimonidine and Chlorpromazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine is an alpha-2 agonist that can cause drowsiness and lowered blood pressure, mainly with systemic absorption from ophthalmic use. Combined with chlorpromazine, a sedating phenothiazine, sedation and hypotension may be additive. The effect is generally modest with eye drops.
What this interaction means in plain words
Brimonidine and Chlorpromazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brimonidine belongs to Miscellaneous; Chlorpromazine belongs to Central Nervous System.
Why it happens
Additive CNS depression and hypotensive effects from alpha-2 agonism and phenothiazine activity.
What to do
Counsel the patient about drowsiness and dizziness, especially when starting therapy. Monitor blood pressure in patients prone to orthostasis.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Brimonidine with Chlorpromazine?
MediHelp rates the interaction as minor. Brimonidine and Chlorpromazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brimonidine is an alpha-2 agonist that can cause drowsiness and lowered blood pressure, mainly with systemic absorption from ophthalmic use. Combined with chlorpromazine, a sedating phenothiazine, sedation and hypotension may be additive. The effect is generally modest with eye drops.
How serious is the interaction between Brimonidine and Chlorpromazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about drowsiness and dizziness, especially when starting therapy. Monitor blood pressure in patients prone to orthostasis.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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