Drug interactions
Brodalumab + Tacrolimus
Severity: Minor
Brodalumab and Tacrolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Blocking IL-17 signaling may normalize CYP450 expression that was suppressed by chronic inflammation. This could alter tacrolimus clearance, but a clinically meaningful effect is theoretical.
What this interaction means in plain words
Brodalumab and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brodalumab belongs to Miscellaneous; Tacrolimus belongs to Miscellaneous.
Why it happens
Cytokine modulation may change CYP3A expression and tacrolimus metabolism; not firmly established.
What to do
Check tacrolimus trough levels after starting or stopping brodalumab and adjust dose if levels change.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Brodalumab
- Brodalumab + Upadacitinib Major
- Brodalumab + Warfarin Moderate
- Brodalumab + Carbamazepine Minor
- Brodalumab + Clonidine Minor
- Brodalumab + Cyclosporin Minor
- Brodalumab + Phenytoin Minor
Frequently asked questions
Can I take Brodalumab with Tacrolimus?
MediHelp rates the interaction as minor. Brodalumab and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Blocking IL-17 signaling may normalize CYP450 expression that was suppressed by chronic inflammation. This could alter tacrolimus clearance, but a clinically meaningful effect is theoretical.
How serious is the interaction between Brodalumab and Tacrolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check tacrolimus trough levels after starting or stopping brodalumab and adjust dose if levels change.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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