Drug interactions
Bromocriptine + Crizotinib
Severity: Moderate
Bromocriptine and Crizotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib inhibits CYP3A4 and can raise concentrations of CYP3A substrates such as bromocriptine. Increased dopaminergic adverse effects like nausea, hypotension, dizziness and somnolence may result.
What this interaction means in plain words
Bromocriptine and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bromocriptine belongs to Central Nervous System; Crizotinib belongs to Oncology.
Why it happens
Crizotinib inhibits CYP3A4, reducing the metabolic clearance of bromocriptine.
What to do
Start with a lower bromocriptine dose and monitor blood pressure and dopaminergic adverse effects. Reduce the dose if intolerance occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bromocriptine
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Bromocriptine with Crizotinib?
MediHelp rates the interaction as moderate. Bromocriptine and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib inhibits CYP3A4 and can raise concentrations of CYP3A substrates such as bromocriptine. Increased dopaminergic adverse effects like nausea, hypotension, dizziness and somnolence may result.
How serious is the interaction between Bromocriptine and Crizotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a lower bromocriptine dose and monitor blood pressure and dopaminergic adverse effects. Reduce the dose if intolerance occurs.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
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