Drug interactions
Bromocriptine + Flibanserin
Severity: Moderate
Bromocriptine and Flibanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bromocriptine is a CYP3A4 substrate and is not an established CYP3A4 inhibitor, so a pharmacokinetic rise in flibanserin is doubtful. Both drugs may cause hypotension, dizziness, somnolence and syncope.
What this interaction means in plain words
Bromocriptine and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bromocriptine belongs to Central Nervous System; Flibanserin belongs to Genitourinary.
Why it happens
Additive hypotensive and sedative effects; CYP3A4 inhibition is not well established.
What to do
Monitor blood pressure and for dizziness, syncope and sedation. Advise avoiding alcohol and driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Bromocriptine
Frequently asked questions
Can I take Bromocriptine with Flibanserin?
MediHelp rates the interaction as moderate. Bromocriptine and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bromocriptine is a CYP3A4 substrate and is not an established CYP3A4 inhibitor, so a pharmacokinetic rise in flibanserin is doubtful. Both drugs may cause hypotension, dizziness, somnolence and syncope.
How serious is the interaction between Bromocriptine and Flibanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for dizziness, syncope and sedation. Advise avoiding alcohol and driving until the response is known.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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