Drug interactions
Bromocriptine + Fluphenazine
Severity: Moderate
Bromocriptine and Fluphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine blocks dopamine receptors and opposes the dopamine agonist effect of bromocriptine. This can reduce efficacy in Parkinson disease or hyperprolactinemia and worsen psychosis.
What this interaction means in plain words
Bromocriptine and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bromocriptine belongs to Central Nervous System; Fluphenazine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at dopamine D2 receptors.
What to do
Avoid combining when possible; monitor symptom control and prolactin. Use quetiapine or clozapine if an antipsychotic is needed in Parkinson disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Bromocriptine
Frequently asked questions
Can I take Bromocriptine with Fluphenazine?
MediHelp rates the interaction as moderate. Bromocriptine and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluphenazine blocks dopamine receptors and opposes the dopamine agonist effect of bromocriptine. This can reduce efficacy in Parkinson disease or hyperprolactinemia and worsen psychosis.
How serious is the interaction between Bromocriptine and Fluphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining when possible; monitor symptom control and prolactin. Use quetiapine or clozapine if an antipsychotic is needed in Parkinson disease.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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