Drug interactions
Bromocriptine + Haloperidol
Severity: Major
Bromocriptine and Haloperidol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol is a potent D2 antagonist and opposes the effect of bromocriptine. This can blunt prolactin suppression and worsen Parkinson symptoms, while bromocriptine may worsen psychosis.
What this interaction means in plain words
Bromocriptine and Haloperidol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bromocriptine belongs to Central Nervous System; Haloperidol belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at dopamine D2 receptors.
What to do
Avoid the combination. In Parkinson disease with psychosis, use quetiapine or clozapine, or pimavanserin.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Bromocriptine
Frequently asked questions
Can I take Bromocriptine with Haloperidol?
MediHelp rates the interaction as major. Bromocriptine and Haloperidol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Haloperidol is a potent D2 antagonist and opposes the effect of bromocriptine. This can blunt prolactin suppression and worsen Parkinson symptoms, while bromocriptine may worsen psychosis.
How serious is the interaction between Bromocriptine and Haloperidol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. In Parkinson disease with psychosis, use quetiapine or clozapine, or pimavanserin.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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