Drug interactions
Bromocriptine + Iloperidone
Severity: Moderate
Bromocriptine and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is an antipsychotic with D2 antagonism that opposes the dopaminergic action of bromocriptine. Efficacy of bromocriptine may be reduced, and dopamine agonists may worsen psychosis.
What this interaction means in plain words
Bromocriptine and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bromocriptine belongs to Central Nervous System; Iloperidone belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at dopamine D2 receptors.
What to do
Monitor for loss of bromocriptine effect and for psychotic symptoms; consider an alternative antipsychotic with less D2 antagonism such as quetiapine if clinically appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bromocriptine
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Bromocriptine with Iloperidone?
MediHelp rates the interaction as moderate. Bromocriptine and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone is an antipsychotic with D2 antagonism that opposes the dopaminergic action of bromocriptine. Efficacy of bromocriptine may be reduced, and dopamine agonists may worsen psychosis.
How serious is the interaction between Bromocriptine and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of bromocriptine effect and for psychotic symptoms; consider an alternative antipsychotic with less D2 antagonism such as quetiapine if clinically appropriate.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
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