Drug interactions
Bromocriptine + Itraconazole
Severity: Major
Bromocriptine and Itraconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole can markedly increase bromocriptine concentrations. This may cause nausea, hypotension, dizziness, somnolence or other dopaminergic adverse effects.
What this interaction means in plain words
Bromocriptine and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bromocriptine belongs to Central Nervous System; Itraconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated bromocriptine metabolism.
What to do
Avoid the combination where possible. If used, start with a reduced bromocriptine dose and monitor blood pressure and dopaminergic adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Bromocriptine
Frequently asked questions
Can I take Bromocriptine with Itraconazole?
MediHelp rates the interaction as major. Bromocriptine and Itraconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole can markedly increase bromocriptine concentrations. This may cause nausea, hypotension, dizziness, somnolence or other dopaminergic adverse effects.
How serious is the interaction between Bromocriptine and Itraconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used, start with a reduced bromocriptine dose and monitor blood pressure and dopaminergic adverse effects.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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