Drug interactions
Bromocriptine + Lomitapide
Severity: Moderate
Bromocriptine and Lomitapide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bromocriptine is a weak CYP3A4 inhibitor and may raise lomitapide exposure, which is metabolized mainly by CYP3A4. Higher lomitapide levels increase the risk of gastrointestinal effects and hepatotoxicity.
What this interaction means in plain words
Bromocriptine and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bromocriptine belongs to Central Nervous System; Lomitapide belongs to Cardiovascular.
Why it happens
Bromocriptine weakly inhibits CYP3A4, decreasing lomitapide metabolism.
What to do
Limit the lomitapide dose in line with labeling for weak CYP3A4 inhibitors and monitor liver enzymes and GI tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bromocriptine
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Bromocriptine with Lomitapide?
MediHelp rates the interaction as moderate. Bromocriptine and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bromocriptine is a weak CYP3A4 inhibitor and may raise lomitapide exposure, which is metabolized mainly by CYP3A4. Higher lomitapide levels increase the risk of gastrointestinal effects and hepatotoxicity.
How serious is the interaction between Bromocriptine and Lomitapide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the lomitapide dose in line with labeling for weak CYP3A4 inhibitors and monitor liver enzymes and GI tolerability.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
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