Drug interactions
Bromocriptine + Lonafarnib
Severity: Major
Bromocriptine and Lonafarnib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a CYP3A4 inhibitor and may raise bromocriptine levels, while bromocriptine as a weak CYP3A4 inhibitor may modestly raise lonafarnib exposure. Increased exposure to either drug could worsen adverse effects, including hypotension with bromocriptine and gastrointestinal toxicity or arrhythmia risk with lonafarnib.
What this interaction means in plain words
Bromocriptine and Lonafarnib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bromocriptine belongs to Central Nervous System; Lonafarnib belongs to Miscellaneous.
Why it happens
Mutual CYP3A4 inhibition, with lonafarnib being a sensitive CYP3A substrate and inhibitor.
What to do
Avoid the combination if an alternative exists; if unavoidable, monitor blood pressure, heart rhythm and symptoms such as syncope or palpitations, and keep lonafarnib at its starting dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Bromocriptine
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Bromocriptine with Lonafarnib?
MediHelp rates the interaction as major. Bromocriptine and Lonafarnib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lonafarnib is a CYP3A4 inhibitor and may raise bromocriptine levels, while bromocriptine as a weak CYP3A4 inhibitor may modestly raise lonafarnib exposure. Increased exposure to either drug could worsen adverse effects, including hypotension with bromocriptine and gastrointestinal toxicity or arrhythmia risk with lonafarnib.
How serious is the interaction between Bromocriptine and Lonafarnib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if an alternative exists; if unavoidable, monitor blood pressure, heart rhythm and symptoms such as syncope or palpitations, and keep lonafarnib at its starting dose.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
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