Drug interactions
Bromocriptine + Lurasidone
Severity: Moderate
Bromocriptine and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone blocks dopamine D2 receptors, while bromocriptine stimulates them. The antipsychotic can therefore blunt bromocriptine's effect in hyperprolactinemia or Parkinson disease, and bromocriptine may worsen psychosis.
What this interaction means in plain words
Bromocriptine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bromocriptine belongs to Central Nervous System; Lurasidone belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism between D2 receptor blockade and D2 agonism.
What to do
Avoid the combination where possible, especially in Parkinson disease, where quetiapine or clozapine are preferred antipsychotics. If used, monitor motor symptoms, prolactin and psychiatric status.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Bromocriptine
Frequently asked questions
Can I take Bromocriptine with Lurasidone?
MediHelp rates the interaction as moderate. Bromocriptine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone blocks dopamine D2 receptors, while bromocriptine stimulates them. The antipsychotic can therefore blunt bromocriptine's effect in hyperprolactinemia or Parkinson disease, and bromocriptine may worsen psychosis.
How serious is the interaction between Bromocriptine and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, especially in Parkinson disease, where quetiapine or clozapine are preferred antipsychotics. If used, monitor motor symptoms, prolactin and psychiatric status.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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