Drug interactions
Bromocriptine + Midazolam
Severity: Minor
Bromocriptine and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bromocriptine is a CYP3A4 substrate with weak inhibitory potential, so an increase in midazolam exposure is minor at most. Both drugs can cause drowsiness and hypotension, so additive sedation is possible.
What this interaction means in plain words
Bromocriptine and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bromocriptine belongs to Central Nervous System; Midazolam belongs to Central Nervous System.
Why it happens
Additive CNS effects, with possible slight CYP3A4 competition.
What to do
Titrate midazolam cautiously and monitor sedation and blood pressure.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Bromocriptine
Frequently asked questions
Can I take Bromocriptine with Midazolam?
MediHelp rates the interaction as minor. Bromocriptine and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bromocriptine is a CYP3A4 substrate with weak inhibitory potential, so an increase in midazolam exposure is minor at most. Both drugs can cause drowsiness and hypotension, so additive sedation is possible.
How serious is the interaction between Bromocriptine and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate midazolam cautiously and monitor sedation and blood pressure.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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