Drug interactions
Bromocriptine + Perphenazine
Severity: Major
Bromocriptine and Perphenazine: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine blocks dopamine D2 receptors, which opposes the dopamine agonist action of bromocriptine. This can reduce its effect in hyperprolactinemia, acromegaly or Parkinson disease. Parkinsonian symptoms may also worsen.
What this interaction means in plain words
Bromocriptine and Perphenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bromocriptine belongs to Central Nervous System; Perphenazine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at dopamine D2 receptors.
What to do
Avoid the combination where possible. If an antipsychotic is needed in Parkinson disease, choose a low-D2-affinity agent such as quetiapine or clozapine.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bromocriptine and Perphenazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Bromocriptine
Frequently asked questions
Can I take Bromocriptine with Perphenazine?
MediHelp rates the interaction as major. Bromocriptine and Perphenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Perphenazine blocks dopamine D2 receptors, which opposes the dopamine agonist action of bromocriptine. This can reduce its effect in hyperprolactinemia, acromegaly or Parkinson disease. Parkinsonian symptoms may also worsen.
How serious is the interaction between Bromocriptine and Perphenazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If an antipsychotic is needed in Parkinson disease, choose a low-D2-affinity agent such as quetiapine or clozapine.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
