Drug interactions
Bromocriptine + Tacrolimus
Severity: Moderate
Bromocriptine and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bromocriptine has been reported to raise tacrolimus concentrations in transplant patients. Higher tacrolimus levels can cause nephrotoxicity, neurotoxicity and other toxicity.
What this interaction means in plain words
Bromocriptine and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bromocriptine belongs to Central Nervous System; Tacrolimus belongs to Miscellaneous.
Why it happens
Probable competition for CYP3A4 metabolism, reducing tacrolimus clearance.
What to do
Measure tacrolimus trough levels and renal function when starting or stopping bromocriptine, and adjust the tacrolimus dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bromocriptine
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Bromocriptine with Tacrolimus?
MediHelp rates the interaction as moderate. Bromocriptine and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bromocriptine has been reported to raise tacrolimus concentrations in transplant patients. Higher tacrolimus levels can cause nephrotoxicity, neurotoxicity and other toxicity.
How serious is the interaction between Bromocriptine and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure tacrolimus trough levels and renal function when starting or stopping bromocriptine, and adjust the tacrolimus dose accordingly.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
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