Drug interactions
Brompheniramine + Dantrolene
Severity: Moderate
Brompheniramine and Dantrolene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brompheniramine is a sedating first-generation antihistamine, and combined with dantrolene it can increase drowsiness, dizziness and weakness. Alertness and coordination may be noticeably impaired.
What this interaction means in plain words
Brompheniramine and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Dantrolene belongs to Musculoskeletal.
Why it happens
Additive CNS depression via central H1 antagonism and dantrolene's central effects.
What to do
Advise against driving and alcohol use, or choose a non-sedating antihistamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Dantrolene?
MediHelp rates the interaction as moderate. Brompheniramine and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brompheniramine is a sedating first-generation antihistamine, and combined with dantrolene it can increase drowsiness, dizziness and weakness. Alertness and coordination may be noticeably impaired.
How serious is the interaction between Brompheniramine and Dantrolene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise against driving and alcohol use, or choose a non-sedating antihistamine.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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