Drug interactions
Brompheniramine + Mirtazapine
Severity: Moderate
Brompheniramine and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brompheniramine is a sedating first-generation antihistamine, and mirtazapine has potent antihistaminic activity. Together they can produce marked drowsiness and impaired psychomotor function, with anticholinergic effects possible from the antihistamine.
What this interaction means in plain words
Brompheniramine and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive H1 receptor blockade and CNS depression.
What to do
Prefer a non-sedating antihistamine such as loratadine or fexofenadine when an antihistamine is needed. If used together, warn about driving and avoid alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Mirtazapine?
MediHelp rates the interaction as moderate. Brompheniramine and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brompheniramine is a sedating first-generation antihistamine, and mirtazapine has potent antihistaminic activity. Together they can produce marked drowsiness and impaired psychomotor function, with anticholinergic effects possible from the antihistamine.
How serious is the interaction between Brompheniramine and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-sedating antihistamine such as loratadine or fexofenadine when an antihistamine is needed. If used together, warn about driving and avoid alcohol.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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