Drug interactions
Brompheniramine + Modafinil
Severity: Minor
Brompheniramine and Modafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brompheniramine is a sedating antihistamine, whereas modafinil promotes wakefulness, so the two have opposing effects. Modafinil may partly mask drowsiness without reliably restoring psychomotor performance.
What this interaction means in plain words
Brompheniramine and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Brompheniramine belongs to Respiratory; Modafinil belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic effects on CNS arousal (histamine H1 blockade versus wake-promoting action).
What to do
Do not rely on modafinil to offset antihistamine drowsiness when driving or operating machinery; consider a non-sedating antihistamine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Modafinil
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Modafinil?
MediHelp rates the interaction as minor. Brompheniramine and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brompheniramine is a sedating antihistamine, whereas modafinil promotes wakefulness, so the two have opposing effects. Modafinil may partly mask drowsiness without reliably restoring psychomotor performance.
How serious is the interaction between Brompheniramine and Modafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not rely on modafinil to offset antihistamine drowsiness when driving or operating machinery; consider a non-sedating antihistamine.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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