Drug interactions
Brompheniramine + Pregabalin
Severity: Moderate
Brompheniramine and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pregabalin and the sedating antihistamine brompheniramine both depress the CNS. Together they can increase drowsiness, dizziness and impaired concentration, with a risk of respiratory depression in vulnerable patients.
What this interaction means in plain words
Brompheniramine and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Pregabalin belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS depression.
What to do
Use the lowest effective doses and advise against driving and alcohol. Monitor for sedation and respiratory depression, especially in older patients and those with lung disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Brompheniramine and Pregabalin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Pregabalin
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Pregabalin?
MediHelp rates the interaction as moderate. Brompheniramine and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pregabalin and the sedating antihistamine brompheniramine both depress the CNS. Together they can increase drowsiness, dizziness and impaired concentration, with a risk of respiratory depression in vulnerable patients.
How serious is the interaction between Brompheniramine and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and advise against driving and alcohol. Monitor for sedation and respiratory depression, especially in older patients and those with lung disease.
What other medicines interact with Pregabalin?
MediHelp also lists interactions of Pregabalin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Pregabalin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
