Drug interactions
Brompheniramine + Tramadol
Severity: Moderate
Brompheniramine and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sedating antihistamines such as brompheniramine add to the drowsiness caused by tramadol and can impair alertness and psychomotor performance. The effect is more pronounced in older adults.
What this interaction means in plain words
Brompheniramine and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Tramadol belongs to Musculoskeletal.
Why it happens
Additive CNS depression from H1 antagonism and opioid activity.
What to do
Advise patients to avoid driving and alcohol, and consider a non-sedating antihistamine. Monitor older adults for confusion and oversedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Brompheniramine and Tramadol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Tramadol?
MediHelp rates the interaction as moderate. Brompheniramine and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sedating antihistamines such as brompheniramine add to the drowsiness caused by tramadol and can impair alertness and psychomotor performance. The effect is more pronounced in older adults.
How serious is the interaction between Brompheniramine and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid driving and alcohol, and consider a non-sedating antihistamine. Monitor older adults for confusion and oversedation.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
