Drug interactions
Brompheniramine + Trazodone
Severity: Moderate
Brompheniramine and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brompheniramine is a sedating first-generation antihistamine and trazodone is also sedating, so drowsiness and psychomotor impairment may be increased. Anticholinergic effects may add to confusion in older adults.
What this interaction means in plain words
Brompheniramine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Trazodone belongs to Central Nervous System.
Why it happens
Additive CNS depression via H1 antagonism and trazodone's sedative effects.
What to do
Avoid driving or hazardous tasks and consider a non-sedating antihistamine. Use particular care in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Trazodone?
MediHelp rates the interaction as moderate. Brompheniramine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brompheniramine is a sedating first-generation antihistamine and trazodone is also sedating, so drowsiness and psychomotor impairment may be increased. Anticholinergic effects may add to confusion in older adults.
How serious is the interaction between Brompheniramine and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid driving or hazardous tasks and consider a non-sedating antihistamine. Use particular care in older adults.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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