Drug interactions
Brompheniramine + Trimipramine
Severity: Moderate
Brompheniramine and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating and anticholinergic, so combined use can increase drowsiness, impair psychomotor performance and cause anticholinergic effects. Older adults are especially at risk of confusion and falls.
What this interaction means in plain words
Brompheniramine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brompheniramine belongs to Respiratory; Trimipramine belongs to Central Nervous System.
Why it happens
Additive CNS depression and antimuscarinic effects.
What to do
Advise patients to avoid driving and alcohol, and monitor for excessive sedation and anticholinergic effects. Prefer a non-sedating antihistamine where an antihistamine is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Brompheniramine
Frequently asked questions
Can I take Brompheniramine with Trimipramine?
MediHelp rates the interaction as moderate. Brompheniramine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating and anticholinergic, so combined use can increase drowsiness, impair psychomotor performance and cause anticholinergic effects. Older adults are especially at risk of confusion and falls.
How serious is the interaction between Brompheniramine and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid driving and alcohol, and monitor for excessive sedation and anticholinergic effects. Prefer a non-sedating antihistamine where an antihistamine is needed.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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