Drug interactions
Budesonide-formoterol + Digoxin
Severity: Moderate
Budesonide-formoterol and Digoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Formoterol can lower serum potassium and may cause tachycardia or arrhythmia, and hypokalemia increases the sensitivity of the myocardium to digoxin toxicity. This can raise the risk of digoxin-related arrhythmias.
What this interaction means in plain words
Budesonide-formoterol and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide-formoterol belongs to Respiratory; Digoxin belongs to Cardiovascular.
Why it happens
Beta-2 agonist-induced hypokalemia potentiates digoxin cardiac toxicity, with additive proarrhythmic effects.
What to do
Monitor serum potassium and digoxin level and watch for arrhythmia or digoxin toxicity symptoms. Correct hypokalemia promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide-formoterol
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Budesonide-formoterol with Digoxin?
MediHelp rates the interaction as moderate. Budesonide-formoterol and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Formoterol can lower serum potassium and may cause tachycardia or arrhythmia, and hypokalemia increases the sensitivity of the myocardium to digoxin toxicity. This can raise the risk of digoxin-related arrhythmias.
How serious is the interaction between Budesonide-formoterol and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and digoxin level and watch for arrhythmia or digoxin toxicity symptoms. Correct hypokalemia promptly.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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