Drug interactions
Budesonide-formoterol + Fluconazole
Severity: Moderate
Budesonide-formoterol and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole can prolong the QT interval and formoterol may add to this effect. Fluconazole also inhibits CYP3A4, which may modestly raise budesonide exposure with prolonged use.
What this interaction means in plain words
Budesonide-formoterol and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide-formoterol belongs to Respiratory; Fluconazole belongs to Anti Fungals.
Why it happens
Additive QT prolongation, plus CYP3A4 inhibition by fluconazole increasing budesonide levels.
What to do
Monitor ECG and correct potassium and magnesium, especially with higher fluconazole doses or other QT-prolonging drugs. Watch for systemic corticosteroid effects during long courses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide-formoterol
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Budesonide-formoterol with Fluconazole?
MediHelp rates the interaction as moderate. Budesonide-formoterol and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole can prolong the QT interval and formoterol may add to this effect. Fluconazole also inhibits CYP3A4, which may modestly raise budesonide exposure with prolonged use.
How serious is the interaction between Budesonide-formoterol and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and correct potassium and magnesium, especially with higher fluconazole doses or other QT-prolonging drugs. Watch for systemic corticosteroid effects during long courses.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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