Drug interactions
Budesonide-formoterol + Panobinostat
Severity: Major
Budesonide-formoterol and Panobinostat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Panobinostat prolongs the QT interval and its labeling advises against combining it with other QT-prolonging drugs. Formoterol may add to this effect and lower potassium.
What this interaction means in plain words
Budesonide-formoterol and Panobinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Budesonide-formoterol belongs to Respiratory; Panobinostat belongs to Oncology.
Why it happens
Additive QTc prolongation, with beta-agonist induced hypokalemia.
What to do
Avoid if possible. If needed, monitor ECG and electrolytes at baseline and regularly, and keep potassium and magnesium in range.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Budesonide-formoterol
Other interactions of Panobinostat
- Amiodarone + Panobinostat Contraindicated
- Anagrelide + Panobinostat Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
- Dronedarone + Panobinostat Contraindicated
- Haloperidol + Panobinostat Contraindicated
Frequently asked questions
Can I take Budesonide-formoterol with Panobinostat?
MediHelp rates the interaction as major. Budesonide-formoterol and Panobinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Panobinostat prolongs the QT interval and its labeling advises against combining it with other QT-prolonging drugs. Formoterol may add to this effect and lower potassium.
How serious is the interaction between Budesonide-formoterol and Panobinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If needed, monitor ECG and electrolytes at baseline and regularly, and keep potassium and magnesium in range.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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