Drug interactions
Budesonide-formoterol + Trazodone
Severity: Moderate
Budesonide-formoterol and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone can prolong the QT interval, and formoterol may add to arrhythmia risk through hypokalemia and tachycardia. The clinical risk is generally modest at usual doses but is greater with other risk factors.
What this interaction means in plain words
Budesonide-formoterol and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide-formoterol belongs to Respiratory; Trazodone belongs to Central Nervous System.
Why it happens
Additive QT prolongation and beta-2 mediated hypokalemia.
What to do
Monitor ECG in patients with cardiac disease or other QT risks, and check potassium; use the lowest effective trazodone dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide-formoterol
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Budesonide-formoterol with Trazodone?
MediHelp rates the interaction as moderate. Budesonide-formoterol and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone can prolong the QT interval, and formoterol may add to arrhythmia risk through hypokalemia and tachycardia. The clinical risk is generally modest at usual doses but is greater with other risk factors.
How serious is the interaction between Budesonide-formoterol and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG in patients with cardiac disease or other QT risks, and check potassium; use the lowest effective trazodone dose.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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