Drug interactions
Budesonide-formoterol + Trimipramine
Severity: Moderate
Budesonide-formoterol and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants such as trimipramine can prolong QT and may potentiate the cardiovascular effects of beta-agonists, causing tachycardia or arrhythmia. Formoterol hypokalemia adds to the risk.
What this interaction means in plain words
Budesonide-formoterol and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide-formoterol belongs to Respiratory; Trimipramine belongs to Central Nervous System.
Why it happens
Additive QT prolongation and adrenergic cardiovascular effects, with beta-2 mediated hypokalemia.
What to do
Monitor heart rate, ECG and potassium, particularly when starting or increasing doses; consider an alternative if cardiac disease is present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide-formoterol
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Budesonide-formoterol with Trimipramine?
MediHelp rates the interaction as moderate. Budesonide-formoterol and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants such as trimipramine can prolong QT and may potentiate the cardiovascular effects of beta-agonists, causing tachycardia or arrhythmia. Formoterol hypokalemia adds to the risk.
How serious is the interaction between Budesonide-formoterol and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and potassium, particularly when starting or increasing doses; consider an alternative if cardiac disease is present.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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