Drug interactions
Bumetanide + Candesartan-hydrochlorothiazide
Severity: Moderate
Bumetanide and Candesartan-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
A loop diuretic combined with a thiazide gives a strong sequential nephron blockade. This can cause marked diuresis, volume depletion, hypokalemia, hyponatremia and hypomagnesemia, and the ARB adds a risk of hypotension and renal impairment.
What this interaction means in plain words
Bumetanide and Candesartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Candesartan-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive diuretic and electrolyte-wasting effects at different nephron sites.
What to do
Monitor electrolytes including potassium, sodium and magnesium, as well as renal function and volume status. Reduce diuretic doses if hypovolemia or hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Candesartan-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Bumetanide and Candesartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. A loop diuretic combined with a thiazide gives a strong sequential nephron blockade. This can cause marked diuresis, volume depletion, hypokalemia, hyponatremia and hypomagnesemia, and the ARB adds a risk of hypotension and renal impairment.
How serious is the interaction between Bumetanide and Candesartan-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor electrolytes including potassium, sodium and magnesium, as well as renal function and volume status. Reduce diuretic doses if hypovolemia or hypotension occurs.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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