Drug interactions
Bumetanide + Celecoxib
Severity: Moderate
Bumetanide and Celecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib can reduce the diuretic and natriuretic response to bumetanide and may add to renal impairment in volume-depleted patients, which can result in fluid retention and worsened blood pressure control.
What this interaction means in plain words
Bumetanide and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Celecoxib belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal blood flow and sodium excretion, opposing loop diuretic action.
What to do
Monitor weight, edema, blood pressure and serum creatinine, and increase the bumetanide dose if the diuretic response falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Celecoxib?
MediHelp rates the interaction as moderate. Bumetanide and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Celecoxib can reduce the diuretic and natriuretic response to bumetanide and may add to renal impairment in volume-depleted patients, which can result in fluid retention and worsened blood pressure control.
How serious is the interaction between Bumetanide and Celecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor weight, edema, blood pressure and serum creatinine, and increase the bumetanide dose if the diuretic response falls.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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