Drug interactions
Bumetanide + Chlorothiazide
Severity: Moderate
Bumetanide and Chlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a loop diuretic with a thiazide produces sequential nephron blockade and a markedly enhanced diuresis. This can cause pronounced hypokalemia, hyponatremia, hypomagnesemia, volume depletion and renal impairment.
What this interaction means in plain words
Bumetanide and Chlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Chlorothiazide belongs to Cardiovascular.
Why it happens
Additive diuretic and kaliuretic effects from blocking sodium reabsorption at the loop of Henle and distal tubule.
What to do
Monitor serum electrolytes, renal function, weight and blood pressure, especially in the first days of combined therapy. Replace potassium and magnesium as needed and reduce doses if over-diuresis occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bumetanide
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Bumetanide with Chlorothiazide?
MediHelp rates the interaction as moderate. Bumetanide and Chlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a loop diuretic with a thiazide produces sequential nephron blockade and a markedly enhanced diuresis. This can cause pronounced hypokalemia, hyponatremia, hypomagnesemia, volume depletion and renal impairment.
How serious is the interaction between Bumetanide and Chlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum electrolytes, renal function, weight and blood pressure, especially in the first days of combined therapy. Replace potassium and magnesium as needed and reduce doses if over-diuresis occurs.
What other medicines interact with Bumetanide?
MediHelp also lists interactions of Bumetanide with, for example, Amifostine, Amikacin, Captopril-hydrochlorothiazide. The full list is on the Bumetanide page.
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