Drug interactions
Bumetanide + Dapagliflozin-metformin
Severity: Moderate
Bumetanide and Dapagliflozin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics such as bumetanide can modestly raise blood glucose. Combined with dapagliflozin they also increase the risk of volume depletion, hypotension and renal impairment, which in turn may predispose to metformin accumulation.
What this interaction means in plain words
Bumetanide and Dapagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Dapagliflozin-metformin belongs to Endocrine.
Why it happens
Loop diuretics may impair glucose tolerance, and additive diuresis with SGLT2 inhibition causes volume depletion and potential renal function decline.
What to do
Monitor glucose, hydration status and renal function, and consider reducing the diuretic dose when starting dapagliflozin. Hold metformin in cases of acute renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Dapagliflozin-metformin?
MediHelp rates the interaction as moderate. Bumetanide and Dapagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loop diuretics such as bumetanide can modestly raise blood glucose. Combined with dapagliflozin they also increase the risk of volume depletion, hypotension and renal impairment, which in turn may predispose to metformin accumulation.
How serious is the interaction between Bumetanide and Dapagliflozin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose, hydration status and renal function, and consider reducing the diuretic dose when starting dapagliflozin. Hold metformin in cases of acute renal impairment.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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