Drug interactions
Bumetanide + Diclofenac
Severity: Moderate
Bumetanide and Diclofenac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diclofenac can diminish the diuretic and natriuretic effect of bumetanide and increase the risk of renal impairment in volume-depleted patients.
What this interaction means in plain words
Bumetanide and Diclofenac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Diclofenac belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal blood flow and promotes sodium and water retention.
What to do
Monitor weight, fluid status, blood pressure and renal function, and increase the diuretic dose if response is reduced. Avoid prolonged NSAID use in heart failure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Diclofenac?
MediHelp rates the interaction as moderate. Bumetanide and Diclofenac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diclofenac can diminish the diuretic and natriuretic effect of bumetanide and increase the risk of renal impairment in volume-depleted patients.
How serious is the interaction between Bumetanide and Diclofenac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor weight, fluid status, blood pressure and renal function, and increase the diuretic dose if response is reduced. Avoid prolonged NSAID use in heart failure.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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