Drug interactions
Bumetanide + Enalapril-hydrochlorothiazide
Severity: Moderate
Bumetanide and Enalapril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding a loop diuretic to an ACE inhibitor and thiazide causes strong diuresis, which can produce hypotension and acute kidney injury in volume-depleted patients. Hypokalemia, hyponatremia and hypomagnesemia are also more likely.
What this interaction means in plain words
Bumetanide and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Enalapril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive diuretic volume depletion and potassium loss combined with ACE inhibitor reduction of glomerular filtration pressure.
What to do
Monitor blood pressure, renal function and electrolytes after starting or changing doses. Reduce the diuretic dose if volume depletion occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Enalapril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Bumetanide and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding a loop diuretic to an ACE inhibitor and thiazide causes strong diuresis, which can produce hypotension and acute kidney injury in volume-depleted patients. Hypokalemia, hyponatremia and hypomagnesemia are also more likely.
How serious is the interaction between Bumetanide and Enalapril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes after starting or changing doses. Reduce the diuretic dose if volume depletion occurs.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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