Drug interactions
Bumetanide + Etodolac
Severity: Moderate
Bumetanide and Etodolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etodolac can reduce the diuretic and natriuretic response to bumetanide and may worsen fluid retention in heart failure or edema. The combination also increases the risk of acute kidney injury, particularly in volume-depleted patients.
What this interaction means in plain words
Bumetanide and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Etodolac belongs to Musculoskeletal.
Why it happens
NSAIDs inhibit renal prostaglandins needed for loop diuretic action and renal perfusion, reducing natriuresis and glomerular filtration.
What to do
Monitor weight, edema, urine output and renal function, and increase diuretic dose if response is blunted. Avoid NSAIDs in patients with heart failure or renal impairment where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Etodolac?
MediHelp rates the interaction as moderate. Bumetanide and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etodolac can reduce the diuretic and natriuretic response to bumetanide and may worsen fluid retention in heart failure or edema. The combination also increases the risk of acute kidney injury, particularly in volume-depleted patients.
How serious is the interaction between Bumetanide and Etodolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor weight, edema, urine output and renal function, and increase diuretic dose if response is blunted. Avoid NSAIDs in patients with heart failure or renal impairment where possible.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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