Drug interactions
Bumetanide + Fluticasone-vilanterol
Severity: Moderate
Bumetanide and Fluticasone-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics lower serum potassium, and beta2-agonists such as vilanterol can further lower it by driving potassium into cells. The combined effect may promote hypokalemia and arrhythmia, mainly with high doses or in patients with cardiac disease.
What this interaction means in plain words
Bumetanide and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Fluticasone-vilanterol belongs to Respiratory.
Why it happens
Additive hypokalemia from renal potassium wasting by the loop diuretic and beta2-mediated cellular potassium uptake.
What to do
Monitor serum potassium and magnesium, particularly at initiation and in patients with heart disease. Replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Fluticasone-vilanterol?
MediHelp rates the interaction as moderate. Bumetanide and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loop diuretics lower serum potassium, and beta2-agonists such as vilanterol can further lower it by driving potassium into cells. The combined effect may promote hypokalemia and arrhythmia, mainly with high doses or in patients with cardiac disease.
How serious is the interaction between Bumetanide and Fluticasone-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium, particularly at initiation and in patients with heart disease. Replace potassium as needed.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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