Drug interactions
Bumetanide + Fosinopril-hydrochlorothiazide
Severity: Moderate
Bumetanide and Fosinopril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding a loop diuretic to an ACE inhibitor and thiazide increases the risk of volume depletion, hypotension and acute kidney injury, especially at initiation. Combined diuretics also increase loss of potassium, magnesium and sodium.
What this interaction means in plain words
Bumetanide and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Fosinopril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive diuresis and electrolyte loss, with ACE inhibition reducing renal perfusion pressure in volume-depleted patients.
What to do
Monitor blood pressure, renal function and electrolytes (potassium, sodium, magnesium) after starting or changing doses. Lower the diuretic dose if the patient is volume depleted.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Bumetanide and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding a loop diuretic to an ACE inhibitor and thiazide increases the risk of volume depletion, hypotension and acute kidney injury, especially at initiation. Combined diuretics also increase loss of potassium, magnesium and sodium.
How serious is the interaction between Bumetanide and Fosinopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes (potassium, sodium, magnesium) after starting or changing doses. Lower the diuretic dose if the patient is volume depleted.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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