Drug interactions
Bumetanide + Hydrochlorothiazide-losartan
Severity: Moderate
Bumetanide and Hydrochlorothiazide-losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a loop diuretic with a thiazide gives strong sequential nephron blockade, causing marked diuresis, volume depletion, hypokalemia, hyponatremia and hypomagnesemia. Together with losartan, volume depletion can also cause hypotension and acute kidney injury.
What this interaction means in plain words
Bumetanide and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
Additive diuretic and electrolyte-wasting effects at different nephron sites, with volume depletion increasing ARB-related renal risk.
What to do
Monitor electrolytes, renal function, weight and blood pressure, especially in the first weeks. Reduce diuretic doses or supplement potassium and magnesium if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Bumetanide
Frequently asked questions
Can I take Bumetanide with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as moderate. Bumetanide and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a loop diuretic with a thiazide gives strong sequential nephron blockade, causing marked diuresis, volume depletion, hypokalemia, hyponatremia and hypomagnesemia. Together with losartan, volume depletion can also cause hypotension and acute kidney injury.
How serious is the interaction between Bumetanide and Hydrochlorothiazide-losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor electrolytes, renal function, weight and blood pressure, especially in the first weeks. Reduce diuretic doses or supplement potassium and magnesium if needed.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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