Drug interactions
Bumetanide + Irbesartan
Severity: Moderate
Bumetanide and Irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a loop diuretic with an angiotensin receptor blocker can cause hypotension and reduced renal function, particularly in volume-depleted patients. Potassium effects oppose each other and are unpredictable.
What this interaction means in plain words
Bumetanide and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bumetanide belongs to Cardiovascular; Irbesartan belongs to Cardiovascular.
Why it happens
Diuretic-related volume depletion combined with angiotensin II receptor blockade reduces blood pressure and glomerular filtration; the ARB reduces potassium excretion while bumetanide increases it.
What to do
Monitor blood pressure, renal function and serum potassium after starting or changing doses. Reduce the diuretic dose if hypotension or volume depletion develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bumetanide
Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Bumetanide with Irbesartan?
MediHelp rates the interaction as moderate. Bumetanide and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a loop diuretic with an angiotensin receptor blocker can cause hypotension and reduced renal function, particularly in volume-depleted patients. Potassium effects oppose each other and are unpredictable.
How serious is the interaction between Bumetanide and Irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and serum potassium after starting or changing doses. Reduce the diuretic dose if hypotension or volume depletion develops.
What other medicines interact with Bumetanide?
MediHelp also lists interactions of Bumetanide with, for example, Amifostine, Amikacin, Captopril-hydrochlorothiazide. The full list is on the Bumetanide page.
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